Pulmonary diseases are main causes sophie allport zebra of morbidity and mortality worldwide.Current studies show that though specific pulmonary diseases and correlative lung-metabolic deviance own unique pathophysiology and clinical manifestations, they always tend to exhibit common characteristics including reactive oxygen species (ROS) signaling
Community Knowledge about Tuberculosis and Perception about Tuberculosis-Associated Stigma in Pakistan
Tuberculosis- (TB) associated stigma is a well-documented phenomenon with various factors, both individual and societal, manifesting its role in shaping health-seeking behavior and contributing to suboptimal TB care in Pakistan.The objective of this study was to assess TB-related knowledge and perceived stigma among hp pavilion 15-eg1053cl communit
Dynamic Failure Properties of Sandstone Under Radial Gradient Stress and Cyclical Impact Loading
In order to analyze the dynamic fracture responses of surrounding rocks in underground space to cyclic impact loads, a series of dynamic compressive tests were conducted using hollow cylindrical and intact sandstone moondrop quarks specimens under confining pressures corresponding to 5, 10, and 12 MPa, and the hollow cylindrical sandstone were subj
Protein aggregates are associated with replicative aging without compromising protein quality control
Differentiation of cellular lineages is facilitated by asymmetric segregation of fate determinants between dividing cells.In budding yeast, various aging factors segregate to the aging (mother)-lineage, with poorly understood consequences.In this study, we show that yeast mother cells form a protein aggregate during early replicative aging that is
The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies
Abstract Given that hypoxia is a persistent physiological feature of many different solid tumors and a key driver for cancer malignancy, it is thought to be a major target in cancer treatment recently.Tumor-associated macrophages (TAMs) are the most abundant immune cells in the tumor microenvironment (TME), which have a large impact on tumor develo